Get rid of Use or Lose Budgets. So much money is wasted by organizations, buying up anything and everything, so they can use their budget money out of fear of losing it the following fiscal.
Instead, have a streamlined approach to funding where projects are funded by authorization instead of use or lose budgets.
Example: NCI buys new furniture every year because it's in their huge budget. However, NIDCD can't afford to put in a centralized data storage for critical research data because they are less funded. What is more important? Both organizations are under HHS/NIH.